Real Madrid travel to Barcelona without Toni Kroos and Gareth Bale but enjoying a six-point lead to Barcelona in the Liga Santander table. That means that Luis Enrique's men will be the ones having to push and risk the most for the win.
The bookies consider Barcelona the favorites to win this match, but Real Madrid have defied the odds many times in the past, including the last 0-3 win against Atletico de Madrid at the Vicente Calderon.
"They are two great teams playing against each other and we'll see what happens. There are no favourites in the Clásico. It's 50-50 and I don't like what I'm hearing otherwise," said Zidane during the pre-match press conference.
“In games like these, the standings have very little bearing on what happens out on the field," explained Barcelona coach Luis Enrique.
All things considered, Barcelona probably have the right to be considered the favorites here playing at home, but that could also increase Real Madrid's chances as they could play with a counterattacking style of football which benefits their men upfront.
Here's WhoScored's prediction. What's yours?