Ramos and Isco are injured and Real Madrid will publish both medical reports shortly, according to @SergioV_esradio— Lucas Navarrete (@LucasNavarreteM) January 26, 2018
Even though Real Madrid have not published medical reports for these two players, it seems that Ramos will need around two weeks to recover while Isco will miss at least one week.
Apparently, both players got those small injuries during the match against Leganes past Wednesday.
It makes sense for Real Madrid to rest both Ramos and Isco so that they can be completely ready to go when Los Blancos face Paris Saint Germain next month in the Champions League Round of 16. However, Madrid still have to bounce back from their discouraging start to the season if they want to clinch their presence in next year’s edition of the Champions League.
It looks like Nacho will start alongside Varane against Valencia while the BBC of Benzema, Bale and Cristiano Ronaldo will be back in the starting lineup.